| Estrogens HH |
| Also known as: Oestrogens Description Estrogens are a group of Female Sexual Steroid Hormones produced in the Ovaries and (to a lesser extent in males) the Testes. Estrogens are also produced within the Brain by Astrocytes. Biological Function of Estrogens Cardiovascular System Estrogens raise HDL Cholesterol levels and lower LDL Cholesterol
levels. Musculoskeletal System Estrogens inhibit the production of excessive quantities of
Osteoclasts (by inhibiting the production of Interleukin 6). - Supplemental Estrogens only retard the Bone loss associated with
Osteoporosis during the five years following Menopause. Nervous System Estrogens (preferably natural Estrogens identical in chemical structure to those produced endogenously) help to prevent Alzheimer's Disease in post-menopausal women and improve the Mental Function of persons afflicted with Alzheimer's Disease. Estrogens prevent Alzheimer's Disease via numerous mechanisms. research - Estrogens improve Blood Circulation to the Frontal Lobe of the
Brain. Estrogens are speculated to inhibit the deposition of Ceroid in the
Brain. Sexual System The Endometrium develops under the influence of Estrogens (in conjunction with Progesterone): - During the first stages of the Menstrual Cycle, immediately after Menstruation, the Endometrium is at its thinnest. Estrogens cause the Endometrium to change and develop. Estrogens help to prepare the female body for Pregnancy.
Novel Experimental Uses of Estrogens Aging Process Estrogens (specifically topically applied 0.01% Estradiol or 0.3% Estriol; oral Estrogens replacment therapy may also be effective) retard and reverse some aspects of the Aging Process in the Skin. research Hair/Skin Estrogens (applied topically to the Scalp) retard further Hair Loss in persons afflicted with Male Pattern Baldness: research - Caution: topical application of Estrogens causes Scalp fragility and tenderness in some persons. Estrogens (specifically topically applied 0.01% Estradiol or 0.3% Estriol; oral Estrogens replacment therapy may also be effective) retard and reverse some aspects of the Aging Process in the Skin: research - Topical Estrogens increase the moisture content of the Skin.
research - Topical Estrogens decrease Wrinkles (as measured scientifically by
the depth of Wrinkles using Skin profilometry) by between 61% and 100%.
research
These Substances (undesirably) Increase Male Estrogens Levels Alcohols Alcohol (ethanol) increases male Estrogens levels by impairing the Liver's ability to convert Estradiol and Estrone to Estriol.
Other Factors that Increase Male Estrogens Levels Aging Process Estrogens (primarily Estradiol and Estrone) levels in males generally increase in tandem with the progression of the Aging Process. research These Substances Minimize the Toxic Effects of Estrogens Hormones Melatonin helps to prevent the growth of those forms of Cancer that
are caused by excessive exposure to Estrogens.
Pharmaceutical Drugs Tamoxifen is used to prevent Breast Cancer by blocking the receptor sites for Estrogens within the body: - Caution: Tamoxifen increases the risk of Liver Cancer. Phytoestrogens Phytoestrogens are so chemically similar to Estrogens that they bind to the Estrogen Receptors on the Cells within the body: - However Phytoestrogens do not initiate the same biological effects
that true Estrogens exert. Polyphenols Daidzein competes with Estrogens for occupancy of Estrogen Receptors.
research These Substances Lower Estrogens Levels Pharmaceutical Drugs Aromatase Inhibitors lower Estrogens (Estradiol and Estrone) levels (by inhibiting the Aromatase enzyme that catalyzes the conversion of Testosterone to Estradiol and the conversion of Androstenedione to Estrone): research - Note that lower Estrogens levels are only desirable when existing
Estrogens levels are excessive.
These Foods/Herbs Counteract the Potentially Toxic Effects of Estrogens Grains Wheat Bran (10 - 20 grams per day) lowers female Estrogens levels. research
Herbs Chaste Berry lowers elevated Estrogens levels. research
Estrogens Enhance the Function of these Substances Enzymes Estrogens increase the activity of Choline Acetylase in various regions of the Brain. Growth Factors Estrogens increase the Brain's sensitivity to the effects of Nerve Growth Factor (NGF). Minerals Estrogens enhance the retention of Calcium in the Bones. Proteins Estrogens increase the production of Cortisol Binding Globulin (CBG) by the Liver.
Smart Drugs Estrogens increase the effectiveness of Pyrrolidone Derivative Nootropics: - Aniracetam Estrogens Interfere with these Substances Hormones Estrogens inhibit the body's production of Parathormone. Vitamins Estrogens are an enemy of Biotin. Estrogens are an enemy of Vitamin B6.
These Factors Interfere with the Body's Production of Estrogens Metabolism Endurance Exercise reduces womens' levels of Estrogens. research Sexual System Female Menopause causes a decline in female production of Estrogens (and it is for this reason that post-menopausal women are often administered exogenous Synthetic Estrogens (this practice known as Estrogen Replacement Therapy (ERT)): - Synthetic Estrogens differ in their chemical structure to that of
the body's natural Estrogens and can produce toxic side-effects that
exceed those of natural, endogenous Estrogens. For this reason
post-menopausal women are advised to consider the use of natural
Estrogens in ERT (natural are more difficult to procure than Synthetic
Estrogens ). - 80% Estriol
These Substances Interfere with Estrogens Pharmaceutical Drugs Antiestrogens (e.g. Danazol, Tamoxifen) compete with Estrogens for occupancy of Estrogen Receptors.
Other Factors that Interfere with Estrogens Surgery When a woman has had an Hysterectomy that removes her Ovaries, production of Estrogens by (the now non-existent) Ovaries will inevitably cease (although small quantities of Estrogens will continue to be manufactured by the Adrenal Glands). Adrenal Gland production of Estrogens will not be sufficient to prevent Estrogens deficiency in many Hysterectomy patients.
Toxic Effects of Excessive Estrogens The toxic effects of Estrogens only occur when the sum of Estradiol + Estrone exceeds 50% of the body's total Estrogens . (i.e. when the proportion of Estriol is less than 50%).
Immune System Excessive Estrogens production increases the risk of some forms of Cancer: - Estrogens potently stimulate Cell Growth in certain tissues. The
more cells divide, the greater the risk that a genetic mishap will occur
that could lead to the uncontrolled proliferation of Cells characterized
by Cancer, especially: - Pharmaceutical supplementation of Estrogens to postmenopausal
females is a major cause of Endometrial Cancer (due to their Estrone
and/or Estradiol component). Excessive use of exogenous, supplemental Estrogens by postmenopausal women increases their risk of developing Systemic Lupus Erythematosus (SLE).
Metabolism Estrogens inhibit the mobilization of Adipose Tissue from Cellulite for redistribution to other areas of the body (possibly accounting for the greater incidence of Cellulite in females than in males).
Nervous System Excessive Estrogens levels can cause Depression (due to them blocking
the Serotonin manufacturing properties of Vitamin B6).
Sexual System Elevated Estrogens levels or Estrogens activity is suspected of
causing Endometriosis. research Estrogens Dominance (i.e. an excess of Estrogens relative to Progesterone) is a common cause of Uterine Fibroids. research
Controversial Aspects of Estrogen Sexual System It is widely believed that women require additional Estrogens (Estrogen Replacement Therapy) during and after Female Menopause: - During and following Menopause, a significant number of females do
NOT require Estrogen Replacement Therapy - the female body still
produces a small quantity of Estrogens (from Androstenedione within
Adipose Tissue) - Estrogen production merely declines in tandem with the
female body's reduced requirement for Estrogens that were formerly
necessary to prepare her Endometrium for Pregnancy.
Commercial Availability of Supplemental Estrogens The use of synthetic, pharmaceutical Estrogens by postmenopausal females is known as Estrogen Replacement Therapy (ERT).
Oral Products Most forms of supplemental Estrogens are in the form of Synthetic
Estrogens and Synthetic Estrogens are also a component of the
Contraceptive Pill. |