The only way the body can get GH is via injectable GH.

 A simple GH blood test will indicate if GH replenshment is necessary due to low levels in the blood and this is done under the guidance of a physician. Daily or twice daily injections are required. The injections are subcutaneous (just under the skin) and painless. Solal Technologies use a brand of injectable hGH which comes with an easy to use pen type device and a tiny little needle.

 TYPES OF GROWTH HORMONE PRODUCTS ON THE MARKET .

 HGH SECRETAGOGUES : These products contain amino acids, vitamins and other nutraceuticals. One of the major benefits of amino acid therapy is that it stimulates the pituitary gland naturally, thereby causing the secretion of growth hormone in the normal pulsatile manner throughout the day and night. Other than assisting the Pituitary Gland to release GH, the amino acids used in Solal Technologies HGH SERETAGOGUE have many other very important health benefits, see information below Dr Cranton's article on these benefits.

Hgh Plus® is a combination of very potent herbs, amino acids, B Vitamin and Homeopathic Pituitarium. These substances strengthen the pituitary gland, detoxify open the cell membrane and direct the substances to the area where the body can maximize the effect. Stabilixes the endocrine system and assists pituitary gland to release Growth Hormone.

The key to the formulation is the precise method of selecting, preparing, processing, sequencing and extracting the medicinal value from nutrition such as herbs, via the patented process known as Alpha Trisequelene TM.

Homeopathic Pituitarium post. 30x is used and shown to be effective based on the proven principle of “like heals like.” There is complete safety and purity in Pituitarium post. 30x for there is no glandulars or animal products or molecules within the formula. Only the healing and rebuilding properties remain.

SPRAYS : Any products that purport to contain hGH whether in homeopathic or other dilutions must be viewed as fraudulent. See article below by Dr E. Cranton who is the Medical Director of Mount Rainier Clinic, in Yelm , Washington , and Mount Rogers Clinic, in Trout Dale , Virginia . These clinics are anti-aging/prevantative medical clinics.

HGH ORAL OR NASAL SPRAY? I DOUBT IT! - By Dr Cranton

I am frequently asked about various forms of human growth hormone (HGH) allegedly being marketed as a nasal spray, oral spray, tablet, or capsule. In return, I merely state that the following problems must be addressed in valid scientific and legal terms before any such claims can be believed.

HGH is large, fragile protein molecule with a molecular weight of 20,000. It contains 191 amino acids in an exact sequence. Its only source is from human genes, using very expensive and meticulous recombinant DNA technology. HGH from any other source, even from other animals, does not work in humans. There is no other source of HGH. There is absolutely no naturally occurring plant source of HGH. HGH must be made using human genetics. The only safe form of HGH is made by splicing human genes into plant cells and then multiplying those cells in a culture media.

A protein molecule that large cannot penetrate intact membranes to any significant degree. Most would be wasted if it were used in a nasal spray or orally. Manufacturing costs are high. HGH is so expensive that any waste is prohibitively expensive.

The technology to make HGH is patented by large pharmaceutical companies and is restricted by law to their use.

The HGH molecule loses potency very rapidly when dissolved in solution. The molecule is folded and twisted on itself repeatedly. Activity in the body depends on fragile cross linkages between branches of this very large molecule, which hold it in an exact three-dimensional configuration. It works on cell receptors exactly like a key in a lock. Any change in shape blocks HGH activity, even if the chemical formula remains exactly the same. Those cross-linkages break very easily and become unstable soon after dissolving in solution. Only with refrigeration can biological activity be maintained for up to two weeks. That's how fragile the molecule is. How then could activity be maintained in a liquid spray?

For storage and shipping, HGH must be very carefully freeze-dried under a vacuum to become a powder. Even the powder must also be kept refrigerated to maintain activity for more than a few months. Very large pharmaceutical companies with research budgets in the billions of dollars have not been able to solve that problem.

HGH is classified as a pharmaceutical drug, strictly controlled by the FDA under state and federal laws and regulations. It is illegal to sell, prescribe, or dispense HGH except through a licensed pharmacy or clinic, and then only on a doctor's prescription in a bone fide doctor-patient relationship. To do otherwise is a criminal offense under the law.

Research studies proving benefit and safety have been published only for the injectable freeze dried power form of rHGH, taken by injection soon after dissolving in solution.

COMMENTS ON "FACT" SHEETS ACCOMPANYING SOME SUCH PRODUCTS

CLAIM: This is the first orally absorbed HGH, 191 amino acids (protein molecules) which are transported by a proprietary polymer matrix, allowing it to be absorbed in the oral mucosa and then transported directly to the Pituitary Gland.

COMMENT : HGH HAS NO BENEFICIAL EFFECT AT THE PITUITARY GLAND. HGH HAS ITS EFFECT ELSEWHERE IN THE BODY. AFTER ENTERING THE BLOOD STREAM, HGH VERY QUICKLY ATTACHES TO RECEPTORS ON TRILLIONS OF CELLS THROUGHOUT THE BODY. THE PITUITARY GLAND IS THE NORMAL SOURCE OF HGH IN YOUNG ADULTS. THE PITUITARY RELEASES HGH INTO THE CIRCULATION SO THAT IT CAN HAVE IT'S EFFECT ELSEWHERE .

CLAIM: The oral spray avoids inactivation by the liver.

COMMENT: WHEN HGH IS ABSORBED THROUGH THE MUCOUS MEMBRANES OF THE MOUTH OR BY INJECTION IT IS HANDLED IN EXACTLY THE SAME WAY BY THE BODY. ONLY IF ABSORBED THROUGH THE LOWER INTESTINE, AS FOOD IS, WOULD IT GO TO THE LIVER FIRST THROUGH THE PORTAL VENOUS SYSTEM.

CLAIM: Until now, it has been virtually impossible to achieve oral absorption of the large HGH molecule. Previously, the only way was through injection into the bloodstream.

COMMENT: USING PATENTED TECHNOLOGY, THE PHARMACEUTICAL INDUSTRY HAS DEVELOPED WAYS TO PARTIALLY ABSORB SOME DRUGS THROUGH THE SKIN. BUT ONLY FOR SMALL, NON-PROTEIN MOLECULES. INSULIN IS A PROTEIN MOLECULE ONLY HALF AS LARGE AS HGH. IF IT WERE POSSIBLE TO ABSORB THAT KIND OF HORMONE BY MOUTH, BY SPRAY, OR THROUGH MEMBRANES, MILLIONS OF PEOPLE WITH DIABETES WOULD NOT NEED TO TAKE INSULIN BY INJECTION. THE MILLIONS OF DOLLARS SPENT ON RESEARCH TO DO JUST THAT HAS BEEN UNSUCCESSFUL.

CLAIM: HGH Oral Spray vs. Injections? An injection of one international unit (i.u.) is equivalent to 250,000 nanograms (parts per billion).

COMMENT: APPROXIMATELY 350,000 NANOGRAMS (0.375 MILLIGRAMS) EQUALS ONE UNIT OF HGH. A 4-UNIT VIAL CONTAINS APPROX 1.52 MG PURE HGH (1,520,000 NANOGRAMS ).  

CLAIM: Injected HGH goes into the bloodstream and is absorbed by the liver.

COMMENT: SOME HGH IS ALWAYS TAKEN UP BY THE LIVER BECAUSE PART OF ITS ACTIVITY IS IN THE LIVER. OTHERWISE, IT WOULD BE LESS EFFECTIVE. HOWEVER, THE ULTIMATE DISTRIBUTION OF HGH WOULD BE EXACTLY THE SAME THROUGH ORAL OR NASAL TISSUES BY SPRAY (IF THAT WERE POSSIBLE) AS IT IS BY INJECTION.

CLAIM: Any excess BY INJECTION is destroyed or diluted in the blood.

COMMENT: THE HALF-LIFE OF HGH IS ONLY A FEW SECONDS AFTER RELEASE BY THE PITUITARY OR BY INJECTION. HOWEVER, IT IS NOT DESTROYED. IT MUST VERY RAPIDLY ATTACH TO HORMONE RECEPTORS ON CELLS THROUGHOUT THE BODY TO HAVE ITS EFFECT. IT IS NOT WASTED. IT ATTACHES TO TRILLIONS OF CELLS IN THE BODY, ALL TYPES OF CELLS, WITHIN A FEW SECONDS WHERE IT HAS ITS BENEFIT. THAT TAKES ONLY A FEW SECONDS. IT IS NOT DESTROYED, BUT UTILIZED. IF HGH DOES NOT DILUTE IN THE BLOOD TO SPREAD THROUGHOUT THE BODY, IT HAS NO EFFECT. 

CLAIM: This injected dose of HGH acts as a replacement dose, therefore shutting down production of HGH.

COMMENT: REPLACEMENT HGH IS GIVEN FOR ANTI-AGING BENEFITS ONLY AFTER THE PITUITARY HAS ALREADY SHUT DOWN ITS PRODUCTION. IF THE PITUITARY STILL RELEASES EFFECTIVE AMOUNTS OF HGH, THERE IS ABSOLUTELY NO NEED FOR REPLACEMENT. ANTI-AGING HORMONE REPLACEMENT IS REPLACEMENT OF A DEFICIENT HORMONE BY DEFINITION. IF THE BODY PRODUCES ENOUGH, IT IS WASTEFUL AND DANGEROUS TO GIVE MORE. TOO MUCH IS NOT GOOD. IF THE BODY IS NOT PRODUCING ENOUGH, IT IS QUITE SAFE AND BENEFICIAL TO RESTORE LEVELS THAT WERE PRESENT THROUGHOUT EARLY ADULT LIFE. IT IS NOT POSSIBLE TO SHUT DOWN SOMETHING THAT HAS ALREADY SHUT DOWN BECAUSE OF AGING.  

CLAIM: One dose of so-called HGH Oral Spray is 25-50 nanograms (parts per billion) taken three times per day and acts as a stimulator, increasing production of HGH.

COMMENT: 25 NANOGRAMS IS ONLY 1/15,000THS THE EFFECTIVE DOSE, EVEN IF IT COULD BE ABSORBED BY SPRAY. THE BODY HANDLES SUBLINGUAL ABSORPTION EXACTLY AS IT WOULD AN INJECTION. NEITHER STIMULATES PRODUCTION. BOTH WOULD MERELY REPLACE DEFICIENT PRODUCTION.

HYPOTHALAMIC HORMONES EXIST IN THE BRAIN THAT DO STIMULATE THE PITUITARY TO RELEASE HGH. OTHER BRAIN HORMONES ACT TO BLOCK HGH RELEASE. HOWEVER, THOSE HORMONES ARE ALSO CONSIDERED DRUGS AND ARE STRICTLY CONTROLLED BY THE FDA IN RESEARCH STUDIES. MERCK PHARMACEUTICAL COMPANY IS RESEARCHING A PATENTED ORAL TABLET THAT STIMULATES HGH RELEASE, BUT THIS NEW DRUG HAS NOT YET BEEN SHOWN TO BE EITHER SAFE OR EFFECTIVE IN LONG TERM USE. IF MERCK IS SUCCESSFUL, IT'S POSSIBLE THAT AFTER ANOTHER 5 YEARS OR SO THE FDA MAY APPROVE A NEW PRESCRIPTION DRUG TO PROMOTE RELEASE OF HGH BY THE PITUITARY.

CLAIM: There is no over stimulating of HGH by the spray.

COMMENT: THIS CLAIM MAKES NO SENSE. HGH DOES NOT STIMULATE HGH, IT REPLACES LOST PRODUCTION. THE DAILY PRODUCTION OF A 20-YEAR-OLD IS ABOUT 500,000 NANOGRAMS PER DAY. IN A 75 YEAR OLD IT'S ABOUT100, 000. THE GOAL IS TO REPLACE HGH BACK UP CLOSER TO 500,000 NANOGRAMS PER DAY.

CLAIM: There is no shutdown of your body's production of HGH.

COMMENT: WHY GIVE HGH IF THE BODY HAS NOT ALREADY SHUT DOWN PRODUCTION?

CLAIM: Because the spray is not diluted by the blood (8-12 pints in the body), there is no waste.

COMMENT: HGH MUST BE DILUTED BY THE BLOOD OR IT CANNOT REACH THE CELLS IN ALL ORGANS OF THE BODY WHERE IT HAS ITS BENEFIT. THAT IS NOT WASTE, THAT IS BENEFIT.

CLAIM: Compared to the spray, others products are secretagogues, precursors and stimulants, with limited potential for increasing HGH.

COMMENT: IT'S TRUE THAT MOST PRODUCTS BEING MARKETED AS NUTRITIONAL SUPPLEMENTS OR SECRETAGOGUES HAVE LIMITED POTENTIAL FOR INCREASING HGH. HOW A SPRAY CAN BE ANY DIFFERENT IS THE UNANSWERED QUESTION?

SOME SECRETAGOGUES SOLD AS NUTRITIONAL SUPPLEMENTS MAY BE ABLE TO INCREASE PITUITARY HGH RELEASE BY AT UP TO 30%, IF TAKEN IN VERY LARGE DOSES ON A TOTALLY EMPTY STOMACH. A 65-YEAR-OLD PERSON WITH ONLY 30% REMAINING DOES NOT GET MUCH BENEFIT FROM A 30% INCREASE (THAT ONLY INCREASES TO LESS THAN 40% OF A DESIRED LEVEL). AND, THE DOSE REQUIRED TO DO THAT IS QUITE EXPENSIVE. 

CLAIM: What is HGH Oral Spray made from? This signal messenger hormone is a plant-based all natural product made from microorganisms. There are no animal products used, only HGH and other minerals.

COMMENT: THEN THERE IS NO HGH IN THE PRODUCT. HGH STANDS FOR "HUMAN" GROWTH HORMONE. IT EXISTS IN NO OTHER SPECIES OF PLANT OR ANIMAL. 

CLAIM: Have any results been proven? Positive results have been proven in 75% of tested cases (3 out of 4 people).

COMMENT: THEN LET'S SEE TABULATED OBJECTIVE BENEFITS, MEASURED IN A CLINICAL STUDY--NOT JUST BLANKET STATEMENTS, TESTIMONIALS AND MARKETING CLAIMS MADE BY THOSE WHO STAND TO PROFIT FROM SALES. WHERE IS THE RESEARCH DATA?

THE FOLLOWING HAVE BEEN PROVEN BY OBJECTIVE MEASUREMENT IN SCIENTIFIC STUDIES PUBLISHED IN PEER-REVIEWED SCIENTIFIC JOURNALS, BUT ONLY WITH THE INJECTED TRUE HGH.  

• 15% average decrease in fat.
• 8% average increase in muscle and lean body structures.
• Improved skin texture resulting in a more youthful appearance. Skin 7% thicker.
• Fewer skin wrinkles.
• Increased bone density, reversal of osteoporosis.
• Faster healing of any type of injury, fracture, or wound.
• Greatly enhanced immunity and resistance to infection.
• Enhanced brain function, retention of intellect with aging.
• Improved sex drive.
• Improvement in overall physical and mental well being.
• Improvement in sleep disorders, better quality of sleep.
• Improved exercise tolerance.
• Improved mineral balance.
• Improved mood, with less depression and fatigue.

NONE OF THOSE BENEFITS HAVE BEEN OBJECTIVELY MEASURED WITH ORAL TABLETS, CAPSULES OR SPRAYS. 

CLAIM: This is a safe product.

COMMENT: PROBABLY TRUE. HOWEVER, IT IS SAFE AND UNCONTROLLED BY THE FDA ONLY BECAUSE IT DOES NOT CONTAIN HGH. HGH CAN BE DANGEROUS IF NOT USED IN THE PROPER WAY IN SAFE REPLACEMENT DOSES. 

CLAIM: The dosage when taken orally is 1/1000 (100 nanograms) of the dosage physicians use when injecting patients with HGH.

COMMENT: THAT SMALL A DOSE WOULD HAVE NO EFFECT, GOOD OR BAD. 

CLAIM: This stimulating dose works by being absorbed into the feedback system of the Pituitary Gland.

COMMENT: THIS IS A NONSENSE STATEMENT, SEEMINGLY MEANT TO DECEIVE SCIENTIFICALLY UNSOPHISTICATED CONSUMERS. 

CLAIM: FDA approval is not needed. This is a dietary supplement and not a drug. Therefore, under the dietary supplement of DSHEA act, it does not have to be FDA approved.

COMMENT: IF IT CONTAINS HGH, THEN IT IS FDA REGULATED BY LAW! IF IT IS NOT FDA REGULATED IT IS BECAUSE IT DOES NOT CONTAIN HGH. 

CLAIM: It acts as a master balancer for the body. It regenerates and helps to repair the body.

COMMENT: TRUE ONLY FOR THE REAL INJECTED FORM OF HGH IN DOSES OF 300,000 NANOGRAMS OR MORE PER DAY.

Amino Acids in HGH SECRATOGOGUE

ARGININE potently stimulate the immune system, assists with the Aging Process, Cardiovascular System, Digestive System and Lowers total serum Cholesterol levels. Useful for Diabetes Type 2 and Insulin Resistance. Detoxifies the Liver and Alleviates Obesity, facilitates weight loss and lowers Triglyceride levels. Facilitates Muscle Growth. Prevents and alleviates Osteoporosis, useful for Alzheimer's, Sexual System, alleviates Male Impotence, Male Infertility, enhances (male and female) Sexual Desire, enhances (female) Sexual Performance and improves (male) Sexual Performance. Accelerates the healing of Wounds and accelerates the healing of Wounds in people who have undergone Surgery. Important for Skin/Hair.

GLUTAMINE assists with Chemotherapy, Digestive System, helps to repair damage to the Intestines in Colitis patients improves the condition of Crohn's Disease patients Gallbladder. Prevents and alleviates Intestinal Permeability, Gastritis, Irritable Bowel Syndrome and accelerates the healing of Peptic Ulcers and of Gastric Ulcers. Assists with Kidneys, Immune System, Allergies, helps to prevent Bacterial & Viral Diseases. Necessary for (AIDS), Chemotherapy and Radiation, Inflammation, reduces the craving for Carbohydrates and reduces elevated Blood Sugar. Assists with Fatigue and stimulates the regeneration of the Liver. Increases Alertness. Useful for the treatment of (ADD) and Improves Mood, increases Intelligence, assists with Learning ability and Memory.

ORNITHINE stimulates the Immune System and blocks the formation of some forms of Cancer. Increases the size of the Thymus Gland and enhances the regeneration of the Liver. Useful for the treatment of Alzheimer's Disease.

 GLYCINE alleviates under-functioning of the Pituitary Gland. Useful for Enlarged Prostate and improves the health of the Prostate Gland. Assists with Energy, Hypoglycemia, Gout, Long Term Memory and increases Muscle Strength and alleviates Pain by stimulating the production of Endorphins. Glycine improves the health of the Skin heals Wounds and is precursor for the endogenous production of Creatine.  

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5/3/2005 “NEW” ADVANCED HGH SECRETAGOGUE & ANTI-AGING FORMULA LAUNCHED BY SOLAL TECHNOLOGIES

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HGH-ADVANCED

-MULTIPLE ACTION GROWTH HORMONE SECRETAGOGUE ANTI-AGING FORMULA

• Safely elevates Growth Hormone (GH) levels in 4-ways:
• (1)Stimulates GH release; (2)Inhibits Somatostatin; (3)Stimulates GHRH release; (4)Improves pituitary sensitivity
• Opposes the physical appearance of aging:
• Enhances tissue regeneration and healing: organs, skin, hair, nails, lean muscle mass; fat-loss
• Improves mental function and immune response

What is hGH-advanced?

hGH-advanced is an upgrade of hGH Secretagogue, representing the latest research into Growth Hormone secretagogues (precursors and growth hormone releasing stimulants). Research shows that the sectretagogues contained in hGH-advanced stimulate the anterior pituitary gland to release stored growth hormone . Furthermore, only hGH-advanced works in four ways to elevate growth hormone levels by: directly stimulating GH release , inhibiting somatostatin, enhancing the sensitivity of the pituitary to Growth Hormone Releasing Hormone (GHRH), and increasing the sectretion of GHRH.

What is Growth Hormone, Somatostatin and Growth Hormone Releasing Hormone (GHRH)?

Growth Hormone-Releasing Hormone (GHRH) is produced and released by the hypothalamus. It directly stimulates the anterior pituitary to release growth hormone stored in specialised cells in the pituitary, called somatotrophs.

Growth hormone is responsible for tissue regeneration and youthful appearance . However, research has shown that, although the aging pituitary produces adequate growth hormone, its release from the somatotroph cells is reduced with age. Conversely, somatostatin , an inhibitor of growth hormone release, increases with age . The result is sub-optimal levels of growth-hormone from about the age of forty.

What are the benefits of Growth hormone?

Growth hormone mitigates, and may even reverse, many of the major effects of aging , such as muscle weakness , excess body fat deposits, poor skin and hair quality, energy depletion, diminished sex drive, and declining immune function.

In addition, Growth Hormone stimulates the growth of organs that shrink with age -the heart, liver, spleen, kidneys, thymus, and thyroid. Growth hormone stimulates production of insulin-like growth factor (IGF), which helps to optimise communication between the immune, nervous, and hormonal systems.

hGH-advanced uniquely works in all 4 ways to elevate Growth Hormone Levels by:

• Stimulating the somatotroph cells to release Growth Hormone .
• Stimulating the hypothalamus to produce Growth Hormone Releasing Hormone (GHRH)
• Enhancing the sensitivity of the pituitary to the effects of GHRH.
• Opposing the production and GH-suppressing effects of somatostatin

The principle behind the use of the multiple growth hormone releasing compounds contained in hGH-advanced is called “ stacking ”. This means that, since many of the compounds in hGH-advanced stimulate GH release by different mechanisms , taking them together causes a larger releasing effect . The doses of each can be made smaller than normally used, with fewer side effects . These compounds are synergistic when taken together, thereby increasing the effect beyond the additive amounts from each compound.

What does hGH-advanced contain and how does it work? ( per capsule - 722.34mg/per daily dose - 5779mg)

• Arginine aspartate, Lysine and Ornithine, are secretagogue amino acids that stimulate the release of growth hormone from the somatotroph cells in the anterior pituitary gland. Although arginine effectively elevates growth hormone release all by itself 1 . Research by Professor Isidori at the University of Rome found that that the combination of arginine with lysine was 10 times more effective than arginine alone. Dr R. Klatz reports a four-fold increase in GH release with this combination, compared to arginine alone 2 . Arginine aspartate is also an inhibitor of somatostatin (somatostatin inhibits GH release) and is the most effective form of arginine for GH release (it elevates GH release by 60%) 3 . This makes arginine aspartate better than both arginine pyroglutamate and arginine hydrochloride.
• Ornithine hydrochloride: Only Ornithine hydrochloride, not ornithine alpha keto-glutarate (OKG) elevates growth hormone levels . In fact, although OKG is found in many Growth Hormone supplements, it actually DECREASES growth hormone levels and should be AVOIDED 4 .
• Glutamine is the latest amino acid to generate excitement as a GH releaser, thanks to a 1995 study by Tomas C. Welbourne of Louisiana State University College of Medicine in Shreveport 5 . Welbourne showed that a surprising small oral dose of glutamine raised growth hormone levels more than four times , compared with subjects given a placebo. Even more exciting is that age did not diminish the response , since volunteers ages ranged from 32 to 64 years. This trial demonstrated that glutamine both enhances muscular protein synthesis and increases circulating growth hormone levels.
• Niacinamide form of vitamin B 3 , is a highly effective stimulator of Growth Hormone 6 .
• Alpha GPC ( glycerylphosphoryl choline ) and Vitamin B5 (calcium pantothenate): Arginine, ornithine lysine and glutamine cause growth hormone release via the brain's cholinergic nervous system. This system uses acetylcholine -made in the brain from the nutrient choline with the help of the cofactor vitamin B5 -to transmit information between the nerve cells. Alpha-GPC is the optimal form of choline for entering brain tissue. Without adequate amounts of acetylcholine, neither arginine, ornithine, lysine nor glutamine can cause growth hormone release 7 . This is why it is essential to use of the optimal form of choline, alpha-GPC, combined with vitamin B 5 in conjunction with arginine, ornithine, lysine and glutamine. Note: many antihistamines, cold/flu pills, and the non-prescription sedatives diphenhydramine and doxylamine are anticholinergics. These medicines will block the GH-releasing effects of arginine, ornithine, lysine and glutamine.

Alpha-GPC also enhances the sensitivity of the pituitary gland to Growth Hormone Releasing Hormone (GHRH), thereby improving GHRH's ability to stimulate the release of Human Growth Hormone (hGH) 8 . Alpha-GPC also increases the release of Gamma Aminobutyric Acid (GABA) , an important GH releaser in its own right 9 .

• GABA (Gamma aminobutyric acid) increases Growth hormone release 10 .
• Velvet bean Extract , contains 15% L-Dopa, which stimulates the secretion of Growth Hormone Releasing Hormone (GHRH), which in-turn stimulates the release of stored Growth Hormone 11 . Note: It is important that no vitamin B6 is taken at the same time as L-dopa, since vitamin B6 converts L-dopa into dopamine, in the body –and we want L-dopa to enter the brain to stimulate GHRH release, not to be destroyed by the body.
• Vitamin C prevents the spontaneous oxidation of L-Dopa 12 .

What is the dosage?

8 capsules should be taken once daily, at bedtime –on an empty stomach. This means you should not have eaten anything for at least two hours before taking hGH-advanced.  If you experience stomach irritation from taking all 8 capsules once, then the dose can be split into 4 capsules twice daily. However, for greatest effect, it is ideal to take all 8 capsules at bedtime.

Are there any side-effects, contra-indications, warnings or special precautions?

• Rarely, hGH-advanced can cause stomach irritation. If this occurs, then split the once daily dose of 8 capsules, into two daily doses of 4 capsules. Diabetics and borderline diabetics should use hGH-advanced with care since arginine and ornithine might improve or worsen a diabetic condition. Persons who have not completed their bone growth (children and teenagers) and pregnant or lactating women should not use GH releasers except under a physician's supervision.
• Do not take anti-cholinergic medicines with hGH-advanced. Anti-cholinergic medicines include antihistamines, cold/flu pills, and the non-prescription sedatives diphenhydramine and doxylamine. These medicines will block the GH-releasing effects of arginine, ornithine, lysine and glutamine and will render hGH-advanced less effective.
• Do not take vitamin B 6 (pyridoxine) at the same time as hGH-advanced since vitamin B6 converts the L-dopa contained in hGH-adavanced, into dopamine in the body. This is undesirable, since we want L-dopa to enter the brain to stimulate GHRH release, not to be destroyed by the body.

How is hGH-advanced unique?

• Contains the best form of arginine: arginine aspartate, not arginine hydrochloride or arginine pyroglutamate.
• Contains the best form of ornithine: ornithine hydrochloride, not ornithine alpha-ketoglutarate.
• Formulated with the optimal combination of arginine, ornithine, lysine and glutamine, essential for enhanced GH release.
• Works is four ways: GH release (secetagogues), GHRH release, anti-somatostatin and enhancing pituitary sensitivity to GHRH. Other products work in one way only, as secretagogues.
• Formulated according to the theory or stacking, also known as pharmacological synergy. This means that effectiveness is enhanced through the synergy of multiple mechanisms of action.
• Pyridoxine free (Pyridoxine opposes the GHRH releasing effects of L-Dopa)
• Uses the Niacinamide form of Vitamin B3, not the dangerous Xanthinol nicotinate form used in some other products.
• Glycine-free. Glycine is a neuro-excitatory amino acid that can be neuro-toxic.

References:

•  Ghigo, E., et al. Low doses of either intravenously or orally administered arginine are able to enhance growth hormone response to growth hormone releasing hormone in elderly subjects . J Endocrinol Invest. 17(2):113-117, 1994.).

•  Klatz, D.O., Ronald with Kahn, Carol, Grow Young with HGH (New York: 1997, HarperCollins Publishers, Inc.), pages 200, 201, 206, 304. ISBN 0-06-018682-8).

•  Besset A, Bonardet A, Rondouin G, Descomps B, Passouant P ; Increase in sleep related Growth Hormone after chronic arginine aspartate administration in man . Acta Endocrinol (Copenh). 1982 Jan;99(1):18-23 ).

•  Vaubourdolle M, Cynober L, Lioret N ; Influence of ornithine alpha-ketoglutarate on hormonal patterns

•  Welbourne TC . Increased plasma bicarbonate and growth hormone after an oral glutamine load. Am J Clin Nutr 1995;61:1058-61.

•  Kimura N, Kimura N, Cathala G, Baxter JD, Johnson GS ; Nicotinamide and its derivatives increase growth hormone in cultured GH3 cells: role for ADP-ribosylation in modulating specific gene expression ;  DNA. 1983;2(3):195-203.

•  Casanueva, Villanueva, Cabranes, Cabezas-Cerrato, Fernandez-Cruz. Cholinergic mediation of growth hormone secretion elicited by arginine and physical exercise in man. J Clin Endocrin Metab 1984;59(3): 526-30).

•  Ceda, G. P., et al. Glyceryl-phosphorylcholine administration increases the growth hormone responses to GHRH of young and elderly subjects. Horm Metabolism Res. 24(3):119-121, 1992).

•  Ferraro, L., et al. Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine. Neurochem Res. 21(5):547-552, 1996).

•  Cavagnini F, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone secretion in man. Acta Endocrinol (Copenh) 1980;93(2):149-54.

•  Hanew, K., et al. The role of endogenous GHRH in arginine-, insulin-, clonidine- and l-dopa-induced GH release in normal subjects . Eur J Endocrinol. 146(2):197-202, 2002.

•  Pardo, B., et al . Ascorbic acid protects against levodopa-induced neurotoxicity on a catecholamine-rich human neuroblastoma cell line. Mov Disorder. 8(3):278-284, 1993